Morphometric analysis of the effects of high molecular weight sodium hyaluronate and amino acids mixture on face rejuvenation.

BACKGROUND: Skin aging can be observed at various levels in the epidermis, dermis, and dermo-epidermal junction. Reducing the cosmetic effects of skin aging in the facial region is a widespread demand due to common aesthetic concerns. Consequently, many injectable products on the market promise antiaging effects and cosmetic improvements. We aimed to evaluate the cosmetic efficacy of a high molecular weight sodium hyaluronate and amino acids mixture for the facial region using morphometric analysis. METHODS: This study evaluates the morphometric effectiveness of an injectable mixture (high molecular weight sodium hyaluronate, glycine, L-Proline, L-leucine, L-lysine HCL, L-valine, and L-alanine collagen active ingredient) on the mid-face and jawline in women aged 30-55. We used morphological measurements and digital image data to assess changes and determine effectiveness. Various computational methods were applied simultaneously with statistical tests for validation. RESULTS: The hydration assessment showed a significant increase on both sides of the face. A noticeable decrease was observed in gonion angle, bitragion breadth, bigonion breadth, and marionette wrinkle scale. These results suggest combining mechanical and chemical stimulation from the injection and its components (hyaluronic and amino acids) effectively enhances skin quality. CONCLUSIONS: The study indicates that the mechanical stimulation of the injection improves skin quality. Combining hyaluronic and amino acids (collagen, elastin, and pro-synthetic) is a safe and effective alternative for antiaging treatments.

A Cluster Validity Index-Based Objective Criteria for Aesthetic Evaluation of Periorbital Treatment.

Purpose: Dark circles and pigmentation around the eyes are common reasons people see dermatologists. An effective assessment of the severity of infraorbital color and texture differences is critical for determining appropriate treatment. Evaluation of the visual severity of cases is mostly based on visual inspection. Treatment efficiency is often measured using patient questionnaires in many cases. The subjectivity of assessments may lead to a prolonged healing process, misdiagnosis, and excessive use of drugs or chemicals. Patients and Methods: In this study, a computer-aided objective evaluation approach was proposed for grading periorbital facial rejuvenation. This approach is based on the analysis of numerical features extracted from different facial regions in digital images. Healing was objectively graded by evaluating data clusters formed using the extracted features. Accordingly, an increase in the visual similarity between paired facial regions is accepted as an indicator of healing, which directly affects the form of data clusters. An intracluster validity index was measured to evaluate the clusters as dense and well separated. A total of 144 facial regions were extracted and examined, and the automatically calculated grades were compared with expert evaluations. Results: The cosmetic effects of the experimental drug were evaluated during the experiments, and expert grades were accepted as the ground truth. The results show that the proposed automated grading approach can evaluate rejuvenation with an accuracy of up to 0.91 accuracy in the upper orbital region. Conclusion: This study concluded that the proposed data-clustering-based approach is promising and can be functional without any special instruments.

Anatomical Variations and Clinical Significance of the Cerebral Arterial Circle in Turkish Cadavers / Variaciones Anatómicas y Significancia Clínica del Círculo Arterial Cerebral en Cadáveres Turcos

SUMMARY: The structure formed by the arteries, which is of great importance in the irrigation of the brain, is called the cerebral arterial circle (Polygon of Willis). Since the cerebral arterial circle provides brain nutrition, vascularabnormalities in this region are highly relevant. Therefore, the aim of our study was to examine the variations of the cerebral arterial circle in cadavers of Turkish individuals. In our study, 32 human cadavers obtained from three different universities were retrospectively examined. Brain tissue obtained from cadavers by craniotomy was kept in 20 % formaldehyde solution for an average of 10 days for fixation. Cerebral arterial circle diagrams were determined in all cadavers by staining and photographs were taken. As a result of the brain examinations, a variation of the cerebral arterial circle was detected in 24/32 brains. Vascular variations have an important place in congenital variations. For this reason, we believe that our brain study will contribute to clinical studies on this topic by investigating variations of the cerebral arterial circle.

La estructura formada por las arterias que tiene una gran importancia en la irrigación del cerebro se denomina círculo arterial cerebral (Polígono de Willis). Dado que el círculo arterial cerebral proporciona la irrigación cerebral, las anomalías vasculares en esta región son muy relevantes. Por lo tanto, el objetivo de nuestro estudio fue examinar las variaciones del círculo arterial cerebral en cadáveres de individuos turcos. En nuestro estudio, se examinaron retrospectivamente 32 cadáveres humanos obtenidos de tres universidades diferentes. El tejido cerebral de los cadáveres fue obtenido por craneotomía y se mantuvo en solución de formaldehído al 20 %, durante 10 días en promedio para su fijación. Se determinaron los diagramas de círculo arterial cerebral en todos los cadáveres mediante coloración y se tomaron fotografías. Como resultado de los exámenes, se detectó una variación del círculo arterial cerebral en 24/32 de los cerebros. Las variaciones vasculares tienen un lugar importante en las variaciones congénitas. Por esta razón, creemos que nuestro estudio contribuirá a estudios clínicos sobre el tema al pesquisar las variaciones del círculo arterial cerebral.

Assessing the Rejuvenation Effectiveness of a Hyaluronic Acid and Amino Acid Mixture in the Periorbital Region.

Purpose: We performed an assessment of the rejuvenation effect of an amino acid and hyaluronic acid mixture in the periorbital area. Methods: A total of 23 of the 35 participants completed all application sessions and measurements. These 23 women were aged 30-55 years. A hyaluronic acid and amino acid mixture was injected into the participants' periorbital area. Three sessions of application with 15-day intervals were undertaken. Subjects' age, height, weight, smoking status, and sport participation were recorded. A photonumeric dark circle scale and Fitzpatrick's periorbital wrinkling classification were used for evaluation of dark circles and wrinkles in the periorbital area. Anatomical measurements (height of upper and lower eyelids) were done using ImageJ and a skin-analysis system (Observ 520). Results: The 23 women had a mean age of 42.46±9.33 years, mean height 164.46±4.96 cm, and mean weight 63.94±8.26 kg. Before the sessions, the mean heights of the upper eyelids were 1.24±013 cm (right) and 1.21±013 cm (left), while those of the lower eyelids were 0.98±014 cm (right) and 0.97±0.17 cm (left). One month after the third session, mean upper-eyelid heights were 1.30±0.09 cm (right) and 1.28±0.11 cm (left) and lower-eyelid ones 1.02±0.11 cm (right) and 1.02±0.13 cm (left). Dark-circle and wrinkle-scale scores showed significantly positive results between before the sessions and 1 month after the third session. Conclusion: A hyaluronic acid and amino acid mixture can be used to rejuvenation of the periorbital area in women aged 30-55 years.

Protective effect of linoleic acid on liver toxicity induced by methotrexate / Efecto protector del ácido linoleico sobre la toxicidad hepática inducida por metotrexato

SUMMARY: We aimed to investigate the protective effect of linoleic acid on liver toxicity induced by methotrexate. The study was carried out in partnership with the Department of Anatomy and Department of Medical Pharmacology of Çukurova University Faculty of Medicine, using the laboratory facilities of the Department of Medical Pharmacology. Human hepatocyte cell line (CRL- 11233) cells obtained from the American Type Culture Collection Organization (ATCC) were used. Expressions of apoptotic pathway markers, apoptosis inducing factor (AIF), BAX, BCL 2, GADD 153, 78-kDa glucose-regulated protein (GRP78), and CASPASE-3 were evaluated. All analyzes were examined in four groups (Group 1; control, Group 2; linoleic acid given, Group 3; methotrexate given and Group 4; linoleic acid and methotrexate given). The mean ± standard error values of the obtained results as nanogram / milliliter (ng / ml) are in Group I, Group II, Group III and Group IV, respectively; AIF values, 0.4150 ± 0.1208, 0.3633 ± 0.2389, 1.792 ± 0.3611 and 1.077 ± 0.1646, BAX values, 0.900 ± 0.1864, 1.002 ± 0.2098, 8.352 ± 1.467 and 4.295 ± 1.522, BCL 2 values, 13.93 ± 1.198, 13.92 ± 1.739, 2.938 ± 1.059 and 9.250 ± 1.492, GADD 153, 0.7333 ± 0.1751, 0.7067 ± 0.2115, 1.650 ± 0.2950 and 1.237 ± 0.1805, GRP78, 0.4767 ± 0.1804, 0.5233 ± 0.1590, 2.183 ± 0.2639 and 1.112 ± 0.2693, CASPASE-3 values , 1.127 ± 0.2033, 0.8317 ± 0.3392, 13.50 ± 1.871 and 8.183 ± 1.030. It was determined that linoleic acid has a protective effect on methotrexate-induced liver toxicity.

Nuestro objetivo fue investigar el efecto protector del ácido linoleico sobre la toxicidad hepática inducida por metotrexato. El estudio se llevó a cabo en colaboración con el Departamento de Anatomía y el Departamento de Farmacología Médica de la Facultad de Medicina de la Universidad de Çukurova, utilizando las instalaciones del laboratorio del Departamento de Farmacología Médica. Se usaron células de la línea celular de hepatocitos humanos (CRL-11233) obtenidas de la American Type Culture Collection Organisation (ATCC). Se evaluaron las expresiones de marcadores de vías apoptóticas, factor inductor de apoptosis (AIF), BAX, BCL 2, GADD 153, proteína regulada por glucosa de 78 kDa (GRP78) y CASPASE-3. Todos los análisis se examinaron en cuatro grupos (Grupo 1; control, Grupo 2; se administró ácido linoleico, Grupo 3; se administró metotrexato y Grupo 4; se administró ácido linoleico y metotrexato). Los valores medios ± error estándar de los resultados obtenidos como nanogramo/mililitro (ng/ml) se encuentran en el Grupo I, Grupo II, Grupo III y Grupo IV, respectivamente; Valores de AIF, 0,4150 ± 0,1208, 0,3633 ± 0,2389, 1,792 ± 0,3611 y 1,077 ± 0,1646, valores de Bax, 0,900 ± 0,1864, 1,002 ± 0,2098, 8,352 ± 1,467 y 4,295 ± 1,522, BCL 2 valores, 13,93 ± 1,199. 2,938 ± 1,059 y 9,250 ± 1,492, GADD 153, 0,7333 ± 0,1751, 0,7067 ± 0,2115, 1,650 ± 0,2950 y 1,237 ± 0,1805, Grp78, 0,4767 ± 0,1804, 0,5233 ± 0,1590, 2,183, ± 1,263. 1,127 ± 0,2033, 0,8317 ± 0,3392, 13,50 ± 1,871 y 8,183 ± 1,030. Se determinó que el ácido linoleico tiene un efecto protector sobre la toxicidad hepática inducida por metotrexato.

Morphometric and aesthetic analysis of people following application of platelet rich plasma for neck rejuvenation / Análisis morfométrico y estético de personas tras la aplicación de plasma rico en plaquetas para el rejuvenecimiento del cuello

SUMMARY: Several studies have shown beneficial effects of platelet-rich plasma. However, there are very few studies investigating the effectiveness of PRP in the neck region. We aimed to assess the efficacy of PRP injection for neck rejuvenation in females aged 40-55. Fifty-two female consecutive participants had PRP injected and roller applied in three sessions at 3-week intervals. Evaluations were blindly performed by comparing the improvements from the pre- to post-application assessments of anatomical measurements of the neck area based on before and after photography of the participants by two anatomists and three medical aesthetic doctors. The Fitzpatrick Skin Scale, Fitzpatrick Goldman Scale, Wrinkle Assessment Scale (Dedo classification system) and patient satisfaction scale were used for assessment. Additionally, skin stiffness and elasticity, cervicomental angle and jawline angle measurements were performed to analyze anatomical changes in the neck area. The study enrolled 52 volunteers with a mean age of 48.60±5.35 years, mean body weight of 63.21±8.43 kg and mean height of 163.25±4.56 cm. Significant differences were found in the elasticity, jawline angle, cervicomental angle, wrinkling, elasticity G and patient satisfaction scores before and after the treatment. When the results of anatomical parameters and scales are compared, it was revealed that PRP is effective in neck rejuvenation.

RESUMEN: Varios investigaciones han demostrado los efectos beneficiosos del plasma rico en plaquetas. Sin embargo, existen muy pocos estudios que investiguen la efectividad del PRP en la región del cuello. Nuestro objetivo fue evaluar la eficacia de la inyección de PRP para el rejuvenecimiento del cuello en mujeres de 40 a 55 años. A cincuenta y dos mujeres participantes consecutivas se les inyectó PRP y se les aplicó rodillo en tres sesiones a intervalos de 3 semanas. Las evaluaciones se realizaron a ciegas comparando las mejoras de las evaluaciones previas y posteriores a la aplicación de las medidas anatómicas del área del cuello basadas en fotografías de antes y después de los participantes realizadas por dos anatomistas y tres médicos especialistas en cirugía estética. Para la evaluación se utilizaron la escala de piel de Fitzpatrick, la escala de Fitzpatrick Goldman, la escala de evaluación de arrugas (sistema de clasificación Dedo) y la escala de satisfacción del paciente. Además, se realizaron mediciones de rigidez y elasticidad de la piel, ángulo cervicomentoniano y ángulo de la línea de la mandíbula, para analizar los cambios anatómicos en el área del cuello. El estudio inscribió a 52 voluntarios con una edad media de 48,60±5,35 años, un peso corporal medio de 63,21±8,43 kg y una altura media de 163,25±4,56 cm. Se encontraron diferencias significativas en las puntuaciones de elasticidad, ángulo mandibular, ángulo cervicomentoniano, arrugas, elasticidad G y satisfacción del paciente antes y después del tratamiento. Cuando se compararon los resultados de los parámetros anatómicos y las escalas, se reveló que el PRP es eficaz en el rejuvenecimiento del cuello.

Estimation of the maximum length of the humerus from its segments lengths / Estimación de la longitud máxima del húmero a partir de las longitudes de sus segmentos

SUMMARY: Long limb bones and fragmentary portions, such as the humerus, are commonly used and examined in forensic and archaeological investigations. This study aimed to estimate the maximum length of the humerus from the measurements of its segments' lengths in our population. The right and left humeri of 100 dry bones from unknown sexes were included in the study. A total of 28 different segments were obtained from 8 different anatomical landmarks named H0, H1, H2, H3, H4, H5, H6, and H7. The length of each segment was compared with the maximum length of the humerus (MHL). An independent t-test, Pearson's correlation, and linear and multiple regression analyses were performed and statistical significance was assigned to p values <0.05. The differences in the measurements of the right and left humeri were not statistically significant (p > 0.05). All of the humerus segments indicated a high correlation when compared with the maximum humerus length (p < 0.05). The H2-3 segment showed a weak correlation with MHL r = 0.173 (p > 0.05). This study demonstrated that the linear and multiple regression equations can be used to estimate the humerus length from its segments' lengths.

RESUMEN: Los huesos largos de los miembros y las porciones fragmentarias, como el húmero, se usan y examinan comúnmente en investigaciones forenses y arqueológicas. Este estudio tuvo como objetivo estimar la longitud máxima del húmero a partir de las mediciones de las longitudes de sus segmentos. Fueron evaluados 100 húmeros secos, derechos e izquierdos, pertenecientes a individuos adultos, de sexo desconocido. Se obtuvieron 28 segmentos distintos de 8 puntos de referencia anatómicos diferentes, denominados H0, H1, H2, H3, H4, H5, H6 y H7. La longitud de cada segmento se comparó con la longitud máxima del húmero (MHL). Se realizó una prueba t independiente, la correlación de Pearson y análisis de regresión lineal y múltiple y se asignó significación estadística a valores de p <0,05. Las diferencias en las medidas del húmero derecho e izquierdo no fueron estadísticamente significativas (p> 0,05). Todos los segmentos del húmero indicaron una alta correlación en comparación con la longitud máxima del húmero (p <0,05). El segmento H2-3 mostró una correlación débil con MHL r = 0,173 (p> 0,05).Este estudio demostró que las ecuaciones de regresión lineal y múltiple se pueden usar para estimar la longitud del húmero a partir de las longitudes de sus segmentos.

Morphometric study of dried cervical vertebrae / Estudio morfométrico de vértebras cervicales secas

The aim of this study was to emphasize the clinical importance of morphometry and the surgical parameters of the cervical vertebrae. The present study was carried out on ninety six adult dry cervical vertebrae (C3-C7, 96) of unknown gender of Turkish population. The various dimensions of the cervical vertebrae (from C3 to C7) were measured with using a digital caliper accurate to 0.01 mm. Linear parameters including vertebral body anteroposterior width (14.03 mm), vertebral body transverse width (24.45 mm); vertebral body height (10.64 mm); pedicle length (R:5.65±1.91 mm, L:5.65±1.76 mm); pedicle width (R:3.72 mm, L:3.61 mm); lamina height (R:9.87 mm, L:9.86 mm); lamina transverse length (R:13.41 mm, L:13.49 mm); superior articular process anteroposterior width (R:7.26 mm, L:7.46 mm); superior articular process transverse diameter (R: 9.87 mm, L:9.58 mm); superior articular process height (R:16.41 mm, L:16.08 mm); inferior articular process anteroposterior width (R: 7.67 mm, L:7.44 mm); inferior articular process transverse diameter (R: 10.32 mm, L:10.09 mm); inferior articular process height (R:12.72 mm, L:12.67 mm); spinous process length (17.91 mm); uncinate process width (R:4.37 mm, L:3.78 mm); uncinate process height (R:4.58 mm, L:3.93 mm); uncinate process length (R:9.28 mm, L:9.12 mm); vertebral foramen anteroposterior width (13.85 mm); vertebral foramen transverse diameter (20.88 mm); foramen transversarium anteroposterior width (R:4.23 mm, L:4.28 mm); foramen transversarium transverse diameter (R:4.78 mm, L:4.95 mm) were measured. Additionally, the distance of the apex of the uncinate process to foramen transversarium (R:2.91 mm, L:2.70 mm), and the distance of the apex of the uncinate process to intervertebral foramen (R: 5.77 mm, L:5.66 mm) were also calculated. There were found significant differences between two sides in the uncinate process width and height, and distance between uncinate process and foramen transversarium. Present measurements suggest that parameters relevant cervical vertebrae can be used as reference and anatomical landmark for evaluating pathologic changes and minimizing complications in the cervical spine.

El objetivo de este estudio fue enfatizar la importancia clínica de la morfometría y los parámetros quirúrgicos de las vértebras cervicales. El presente estudio se realizó en noventa y seis vértebras cervicales secas adultas (C3-C7) de sexo desconocido de la población turca. Las diversas dimensiones de las vértebras cervicales (C3 a C7) se midieron utilizando un calibrador digital con una precisión de 0,01 mm. Se determinaron parámetros lineales incluyendo ancho anteroposterior del cuerpo vertebral (14,03 mm), ancho transversal del cuerpo vertebral (24,45 mm); altura del cuerpo vertebral (10,64 mm); longitud del pedículo (R: 5.65 ± 1,91 mm, L: 5.65 ± 1,76 mm); ancho del pedículo (R: 3,72 mm, L: 3,61 mm); altura de la lámina (R: 9,87 mm, L: 9,86 mm); longitud transversal de la lámina (R: 13,41 mm, L: 13,49 mm); Diámetro anteroposterior del proceso articular superior (R: 7,26 mm, L: 7,46 mm); Diámetro transversal del proceso articular superior (R: 9,87 mm, L: 9,58 mm); Altura articular superior del proceso (R: 16,41 mm, L: 16,08 mm); Diámetro anteroposterior del proceso articular inferior (R: 7,67 mm, L: 7,44 mm); Diámetro transversal del proceso articular inferior (R: 10,32 mm, L: 10,09 mm); Altura del proceso articular inferior (R: 12,72 mm, L: 12,67 mm); longitud del proceso espinoso (17,91 mm); ancho del proceso uncinado (R: 4,37 mm, L: 3,78 mm); altura de proceso uncinado (R: 4,58 mm, L: 3,93 mm); longitud del proceso uncinado (R: 9,28 mm, L: 9,12 mm); Ancho anteroposterior del foramen vertebral (13,85 mm); Diámetro transverso del foramen vertebral (20,88 mm); Ancho anteroposterior del foramen transverso (R: 4,23 mm, L: 4,28 mm); Diámetro transverso del foramen transverso (R: 4,78 mm, L: 4,95 mm). Además, la distancia del vértice del proceso uncinado al foramen transverso (R: 2,91 mm, L: 2,70 mm) y la distancia del vértice del proceso uncinado al foramen intervertebral (R: 5,77 mm, L: 5,66 mm) Se encontraron diferencias significativas entre los dos lados, en el ancho y la altura del proceso uncinado, y la distancia entre el proceso uncinado y el foramen transverso. Las mediciones actuales sugieren que los parámetros relevantes de las vértebras cervicales se pueden usar como referencia y punto de referencia anatómicos para evaluar los cambios patológicos y minimizar las complicaciones en la columna cervical.

The relationship of finger length ratios (2D: 4D) with quantitative, verbal talent and anthropometric parameters / La relación de las proporciones de la longitud del dedo (2D: 4D) con el parámetro cuantitativo, talento verbal y parámetros antropométricos

SUMMARY: The aim of this study were to investigate the relationship between 2D:4D finger length ratios (the ratio of the second finger length to the fourth finger length) of students from verbal and quantitative weighted fields, and to determine the correlation of these ratios with some anthropometric measurements. For this purpose; hand length, hand width, lengths of second and fourth finger and waist, hip and neck circumferences were taken from totally 398 (199 female, 199 male) students aged 17-25 years by using millimetric callipers and non-elastic standard measuring tape. Demographic data were also taken. Moreover, Body Mass Index (BMI) and 2D:4D finger length ratios of the study group were also calculated. When we investigated the 2D:4D ratios for right, left and dominant hands among verbal and quantitative talented individuals in female students, there were statistically significant differences for right and dominant hand (p=0.032; p=0.042, respectively). On the other hand, there was no difference for left hand in female participants (p>0.05). Furthermore, there were positive correlations with 2D:4D and weight (r=0.38, p<0.001), BMI (r=0.34, p=0.01) of the male students in verballyweighted field and with hip and waist circumferences in male students in quantitatively-weighted field (r=0.30; p=0.002; r=0.41, p<0.001). In male students in quantitatively-weighted fields, there was a weak and positive correlation with 2D:4D finger length ratios and neck circumferences on the left hand, and this relationship was statistically significant (r=0.21; p=0.032). And also, there were no statistically significant correlations between anthropometric measurements and 2D:4D ratios among the female students in quantitatively weighted field. Whereas there were positive correlations with 2D:4D finger length ratios and waist circumference in female students in verbally weighted field (r=0.24, p=0.018). We believe that the data obtained in this study will be a guide for career planning goals of persons according to their quantitative and verbal talents.

RESUMEN: El objetivo de este estudio consistió en investigar la relación entre índices de longitud del dedo (2D:4D) (es decir, la relación de la longitud del segundo dedo a la cuarta longitud del dedo) de los estudiantes de campos ponderados verbales y cuantitativos, para determinar la correlación de estas proporciones con algunas medidas antropométricas. Para este propósito, se consideraron las siguientes mediciones: longitud de la mano, ancho de la mano, circunferencia del segundo y cuarto dedo y circunferencia de cintura, cadera y cuello. Se examinaron 398 estudiantes (199 mujeres, 199 hombres) de 17-25 años de edad, usando pinzas milimétricas y cinta métrica estándar no elástica. También se tomaron datos demográficos. Además, se calcularon las proporciones de índice de masa corporal (IMC) y 2D:4D del grupo de estudio. Cuando investigamos las proporciones 2D:4D para manos derechas, izquierdas y dominantes entre individuos talentosos verbales y cuantitativos en mujeres, hubo diferencias estadísticamente significativas para la mano derecha y dominante (p = 0,032, p = 0,042, respectivamente). Por otro lado, no hubo diferencia para la mano izquierda en las mujeres (p> 0.05). Además, hubo correlaciones positivas con 2D:4D y peso (r = 0,38, p <0,001), IMC (r = 0,34, p = 0,01) de los hombres en el campo verbalmente ponderado y con circunferencias de cadera y cintura en hombres en campo ponderado cuantitativamente (r = 0,30, p = 0,002; r = 0.41, p <0,001). En los hombres, en campos cuantitativamente ponderados, hubo una correlación débil y positiva en 2D, relaciones de longitud de dedo 4D y circunferencias de cuello en la mano izquierda, y esta relación fue estadísticamente significativa (r = 0,21, p = 0,032). También, no hubo correlaciones estadísticamente significativas entre las medidas antropométricas y las proporciones 2D:4D entre las estudiantes en el campo cuantitativamente ponderado. Mientras que hubo correlaciones positivas con 2D:4D, índices de longitud del dedo y circunferencia de la cintura en las mujeres en el campo ponderado verbalmente (r = 0,24, p = 0,018). Creemos que los datos obtenidos en este estudio serán una guía para los objetivos de planificación de carrera de las personas de acuerdo con sus talentos cuantitativos y verbales.

Evaluation of the elbow carrying angle in healthy individuals / Evaluación del ángulo de desplazamiento del codo en individuos sanos

SUMMARY: Carrying angle, or cubital angle defined as the acute angle formed by the median axis of the arm when forearm is in fully extended and supinated position. This angle changes with skelatal growth and maturity. This study was aimed to investigate the correlation of carrying angle with bi-acromial diameter and bi-acromial diameter/bi-trochanteric diameter in our healthy young adult population. This was a cross-sectional study that included 400 (204 male, 196 female) young adult students selected from Çukurova University aged between 18-25 years (mean±standard deviation of females: 20.11±2.05 years; mean±standard deviation of males: 20.45±1.82 years) which originated from different cities in Turkey. After recording demographic data, carrying angle, forearm length, arm length, bi-trochanteric diameter and bi-acromial diameter were measured by using nonelastic tape measure, pelvimeter and manuel goniometer. In addition, body mass index and bi-acromial diameter/bi-trochanteric diameter were calculated for each participants. The mean values of body height and weight were in following respectively for both genders: 178.53±6.40 cm (male), 163.88±5.73 cm (female); 74.89±10.81 kg (male), 57.56±8.61 kg (female). Whereas on dominant arm this angle was as in males 9.77°±2.82° and 13.94°±3.97° in females. The mean value of the carrying angle on nondominant arm in males was 9.85°±2.95° and 14.03°±4.08° in females. The mean carrying angle was 9.81°±2.82° in males and 13.99°±3.97° in females. There are linear relationship between the carrying angle and height (r=-0.474, p<0.001, bi-acromial diameter (r=-0.490, p<0.001), bi-acromial diameter/bi-trochanteric diameter (r=-0.449, p<0.001), forearm length (r=-0.366, p<0.001) and arm length (r=-0.273, p<0.001). We believe that the reference values of carrying angle will help the clinician in the management of elbow displacements, fractures, prosthetic design and diagnosis of epicondylar diseases.

RESUMEN: Se estudió el ángulo de sustentación o ángulo cubital definido como el ángulo agudo formado por el eje mediano del brazo al estar en posición completamente extendido y supinado el antebrazo. Este ángulo cambia con el crecimiento esquelético y la madurez. El objetivo de este estudio fue investigar la correlación del ángulo con el diámetro biacromial y el diámetro bi-acromial / diámetro bi-trocantérico en una población adulta joven y sana. Se realizó un estudio transversal que incluyó 400 (204 hombres, 196 mujeres) estudiantes adultos jóvenes seleccionados de la Universidad de Çukurova con edades comprendidas entre 18-25 años (media ± desviación estándar de las mujeres: 20,11 ± 2,05 años; media ± desviación estándar de los hombres: 20,45 ± 1,82 años) que se originaron en diferentes ciudades de Turquía. Después de registrar los datos demográficos, el ángulo de desplazamiento, la longitud del antebrazo, la longitud del brazo, el diámetro bi-trocantérico y el diámetro biacromial se midieron utilizando cinta métrica no elástica, pelvímetro y goniómetro manual. Además, se calcularon el índice de masa corporal y el diámetro bi-acromial / diámetro bi-trocantérico para cada participante. Los valores medios de la altura y el peso corporal fueron respectivamente para ambos sexos: 178,53 ± 6,40 cm (masculino), 163,88 ± 5,73 cm (femenino); 74,89 ± 10,81 kg (masculino), 57,56 ± 8,61 kg (femenino). Mientras que en el brazo dominante este ángulo fue como en los hombres 9,77° ± 2,82° y 13,94° ± 3,97° en las mujeres. El valor medio del ángulo de transporte en el brazo no dominante en los hombres fue de 9,85° ± 2,95° y de 14,03° ± 4,08° en las mujeres. El ángulo medio de desplazamiento fue de 9,81° ± 2,82° en hombres y 13,99 ° ± 3,97 ° en mujeres. Hay una relación lineal entre el ángulo de desplazamiento y la altura (r = -0,474, p <0,001, diámetro bi-acromial (r = -0,490, p <0,001), diámetro biacromial / diámetro bi-trocantérico (r = -0,449, p <0,001), longitud del antebrazo (r = -0,366, p <0,001) y longitud del brazo (r = -0,273, p <0,001). Creemos que los valores de referencia del ángulo de carga ayudarán al clínico en el manejo de los desplazamientos del codo, las fracturas, el diseño protésico y el diagnóstico de enfermedades epicondilares.

Sonographic determination of normal spleen size in Turkish adults / Determinación ecográfica del tamaño normal del bazo en adultos turcos

The current study was undertaken to determine normal spleen dimensions and anthropometric evaluation by ultrasonography from females and males in our population. These measurements were taken using an ultrasonography. The mean values of the age, height, weight and body mass index (BMI) of subjects, spleen width (SW), spleen length (SL), spleen thickness (ST) and spleen volume calculated with elipsoid formula; length x width x thickness x 0.524 were taken. These measurements were found to be 36.37±10.83 years, 164.22±4.72 cm, 60.26±7.11 kg, 22.30±2.09 kg/m2, 7.58±1.56 cm, 9.87±1.28 cm, 3.34±0.79 cm and 136.05±61.14 cm3 in females respectively. Additionally, in males same dimensions were 40.50±12.77 years, 174.41±6.57 cm, 76.33±8.54 kg, 25.06±2.10 kg/m2, 8.75±1.84 cm, 11.01±1.186 cm, 4.12±1.09 cm and 220.70±115.35 cm3 respectively. The observations presented in this report have defined anatomic parameters about spleen size that need to be taken into consideration for reference data to determine population discrepancies and helpful for radiologists and clinicians.

El objetivo fue determinar las dimensiones normales del bazo y realizar una evaluación antropométrica mediante ecografía en mujeres y hombres turcos. Fueron calculados los valores medios de edad, altura, peso, índice de masa corporal (IMC), ancho del bazo (AB), longitud del bazo (LB) y grosor del bazo (GB), junto al volumen del bazo mediante la fórmula elipsoide (largo x ancho x grosor x 0,524). Las mujeres presentaron una edad de 36,37±10,83 años, altura de 164,22±4,72 cm, peso de 60,26±7,11 kg, IMC de 22,30±2,09 kg/m2, AB de 7,58±1,56 cm, LB de 9,87±1,28 cm, GB de 3,34±0,79 cm y volumen del bazo de 136,05±61,14 cm3. Los hombres presentaron una edad de 40,50±12,77 años, altura de 174,41±6,57 cm, peso de 76,33±8,54 kg, IMC de 25,06±2,10 kg/m2, AB de 8,75±1,84 cm, LB de 11,01±1,186 cm, GB de 4,12±1,09 cm y volumen del bazo de 220,70±115,35 cm3. Nuestras observaciones han definido parámetros anatómicos sobre el tamaño del bazo, los cuales deben ser considerados como datos de referencia para determinar las discrepancias en la población, de utilidad para radiólogos y clínicos.

Anthropometric indices in relation to overweight and obesity among Turkish medical students.

INTRODUCTION: The aim of this study was to present the reference anthropometric data associated with obesity for cardiovascular risk and metabolic diseases for healthy young adults in a Turkish population. MATERIAL AND METHODS: The study group consisted of 1163 second-year medical students (650 women, 513 men) aged 20-25 years from Çukurova University in Adana and the measurements were made using a flexible standard measuring tape. The data were collected during the period 2007-2011. RESULTS: From 1163 medical students, the mean values of body mass index, circumferences of waist, hip, neck, mid-arm, thigh and calf were 20.89 ±1.6 kg/m(2), 73.15 ±5.1 cm, 95.35 ±4.8 cm, 30.32 ±1.37 cm, 24.12 ±1.75 cm, 47.23 ±3.26 cm and 34.36 ±2.19 cm respectively in women, while the same measurements were 21.98 ±1.67 kg/m(2), 77.73 ±5.81 cm, 95.64 ±4.81 cm, 35.61 ±1.43 cm, 25.60 ±1.84 cm, 44.10 ±3.26 cm and 34.92 ±2.08 cm respectively in men. Moreover, waist to hip ratio, waist to height ratio and neck to height ratio were respectively 0.76, 0.44 and 0.18 in women and 0.81, 0.43 and 0.19 in men. CONCLUSIONS: The precise knowledge of anthropometric data could be used as reference values for evaluating the body composition and fat distribution of Turkish young people.

The effects of maternal deprivation on the hippocampal structure in adult rats.

OBJECTIVES: To examine the ultrastructural effects of maternal deprivation during developmental periods of limbic-hypothalamo-pituitary-adrenal system on hippocampal dendritic structures in adult rats. METHODS: The experiments were carried out with male and female Wistar rats in our department. The rats were mated and, after birth, the pups were divided into four groups. The first group (control group) pups remained undisturbed with their dam until postweaning day 22. Maternal deprived groups were separated from their dams for 24 hours at postnatal day 4, 9 and 18. The subjects were provided with food and water ad libitum until 3-months-of-age. At the third month, the rats were transcardially perfused, samples were taken from CA1 and CA3 regions of the hippocampus. Tissues were prepared for electron microscopy. RESULTS: When the data were analyzed, there were no differences between male and female rats in both ultrastructure and semiquantitative analysis of axodendritic synapses. The ultrastructure of Group 1 was seen as normal while in the second Group some neurons nuclear envelope made deep invagination into the nucleus. Additionally, axodendritic synapses were found normal. In Group 3, micrographs and axodendritic synapses were showed normal structure. However, in Group 4 in some neurons invaginations were seen similar to Group 2. Axodendritic synapses were found to be normal. CONCLUSION: These experiments establish that MD in rats produces slight ultrastructural changes and decreases the number of synapses in CA1 and CA3 subregions of the hippocampus.